Stanley Pounds

@ ST. JUDE CHILDREN'S RESEARCH HOSPITAL

🌐 https://www.stjude.org/people/p/stan-pounds.html

Day 2: 09:00-09:40 – PROMISE-ME a Cure

Abstract

This presentation provides the statistical backstory of the very successful multi-center AML16 clinical trial that raised the three-year overall survival of pediatric acute myeloid leukemia (AML) from roughly 75% to 88%. The presentation will describe the philosophical motivation and development of the projection onto the most interesting statistical evidence (PROMISE) method and it’s application to methylation and expression (ME) data that made this exciting advance in curing pediatric AML possible. It will also discuss lessons learned, suggest strategies to replicate this success for other cancers, and propose some directions to explore moving forward.

Short Bio

Dr. Stanley Pounds is a biostatistician with extensive collaborative experience in laboratory and clinical pediatric oncology research. A Member of the St. Jude Faculty, he received his PhD in Statistics from Texas A&M University and serves as Director of Biostatistics Courses at the St. Jude Graduate School of Biomedical Sciences. He is currently developing a biomedical data science program within the St. Jude Graduate School. As a recognized expert in the development and application of innovative data analysis methods for applications in cancer genomics and pharmacogenomics, Pounds leads his laboratory in statistical research that makes practical contributions toward enhancing rigor and impact of collaborative biomedical research.